Dear Editor,Since leaving office in 2011 as the President of the Cooperative Republic of Guyana, former president and present Opposition Leader Dr Bharrat Jagdeo is being used by the APNU/AFC Government to cover up their mismanagement, corruption, incompetence, and inability to create a better life for all Guyanese.Jagdeo is the only person who could be compared with Dr Cheddi Jagan as a true patriot; as a person who is truly connected to the masses; as a person who walks the walk and talks the talk with the people; as a visionary leader, a person who fights for the rights of the poor; and as the most popular political figure in Guyana and the Caribbean.Dr Bharrat Jagdeo is recognised with high standing internationally. With these eminent qualities in mind, persons are very envious of this great personality, not only in the coalition camp, but others who are ambitious and wicked.Let me compliment Sherwood Lowe for his letter that he has written concerning the CCJ ongoing case with the third term of presidential candidate. It is very factual and informative.I am convinced that Bharrat Jagdeo will be the only person who would give the PPP a landslide victory for the 2020 elections. With any other presidential candidate, the PPP will have to campaign real hard for a landslide victory.I challenge the AFC/APNU coalition Government that if Bharrat Jagdeo is not credible, then they don’t need to campaign for the 2020 elections. I think desperation is stepping in the coalition camp, because Jagdeo as the presidential candidate is a sure win for the PPP/C in the 2020 elections.A win for the Jagdeo/PPP is a win for the people.Sincerely,Zamal Hussain
Excluding one-time charges, HP said it earned $1.8 billion, or 65 cents per share, beating analyst forecasts. Analysts were expecting HP to earn, on average, 62 cents per share on $24.3 billion in revenue, according to a survey by Thomson Financial. The company continued to profit from substantial market-share gains at the expense of struggling rival Dell Inc., which has lost its title of No. 1 seller of PCs worldwide to HP in recent quarters. HP built on that momentum in the second quarter, when revenue from laptop sales rose 40 percent. However, revenue from the sale of desktop computers, which are waning in popularity as their portable counterparts become more pervasive, fell 1 percent. HP also posted strong numbers in its lucrative Imaging and Printing Group, which makes the consumer and business printers and supplies that provide the bulk of the company’s profits. SAN FRANCISCO – Hewlett-Packard Co.’s first-quarter profit jumped 26 percent as the company benefited from higher sales of laptop computers, printers and printing supplies during a robust holiday spending season. The results beat Wall Street’s expectations, but concerns about mounting inventory and investors’ assumptions that HP would beat analyst estimates by even more helped send the stock price down slightly in after-hours trading. HP said Tuesday that it earned $1.55 billion, or 55 cents per share, for the quarter ended Jan. 31, compared with $1.23 billion, or 42 cents per share, for the same period last year. The Palo Alto-based computer and printer maker said revenue for the period was $25.1 billion, compared with $22.7 billion during the same quarter last year. Operating profit for that business unit increased 10 percent over last year, to $1.1 billion or 15.3 percent of revenue. However, HP is now facing increasing competition in that market with Eastman Kodak Co.’s launch of a line of competing inkjet-printer products. “HP delivered a strong first quarter, with improved margins and solid revenue growth across our businesses,” Mark Hurd, HP’s chairman and chief executive officer, said in a statement. “We have a lot of work and opportunities ahead of us. I am confident we can continue to execute with discipline and deliver a year of strong financial returns.” HP’s stock gained 36 cents to close at $43.13 on the New York Stock Exchange before the results were released. In after-hours trading, HP shares fell 53 cents, to $42.60. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
Republic of Ireland captain John O’Shea battles Scotland’s Steven Naismith John O’Shea’s unfortunate own goal denied the Republic of Ireland revenge over Scotland as their hopes of Euro 2016 qualification suffered a fresh blow in Dublin.The hosts dominated an occasionally tetchy game and took a deserved lead through Jon Walters on 38 minutes.However, the Stoke star did appear to be in an offside position as he stabbed home from close-range, after David Marshall saved Daryl Murphy’s bullet header from a corner.Scotland took little time to respond after the break, with Shaun Maloney seeing his curling shot, which was heading wide, going in off O’Shea’s shoulder just two minutes into the second half.Ireland had the chance to take back their lead minutes later, but glovesman Marshall produced another crucial save to keep out the impressive Murphy for a second time; the Ipswich forward played clean though but seeing his effort flicked wide by the goalkeeper’s legs.Martin O’Neill side shrugged off the blow and roared back, with Robbie Keane – who was introduced off the bench late on at the end of a difficult week – going close with a cleverly crafted chance.But the visitors held out, unconvincingly at times, for the point to go above Germany into second place in Group D.The world champions, however, should restore their advantage later in the evening against Gibraltar, while leaders Poland showed again their qualifying credentials with a 4-0 win over Georgia. 1
Arsenal left back Sead Kolasinac will miss eight to ten weeks with a knee injury.The Bosnian was substituted during the Gunners’ pre-season friendly against Chelsea on Wednesday, and the club have now confirmed the severity of his issue. How the Premier League table could change after the Boxing Day fixtures Kolasinac was injured as Arsenal drew 1-1 with Chelsea in Dublin How Arsenal could line up in Arteta’s first official game in charge – Ozil return? BIG PRESENTS UP TOP REVEALED possible standings Every current Premier League club’s best kit from the past decade Latest Arsenal News England’s most successful clubs of the past decade, according to trophies won smart causal What every Premier League club’s fans dream of this Christmas NEW ERA 1 Where every Premier League club needs to strengthen in January silverware targets gameday cracker Boxing Day fixtures: All nine Premier League games live on talkSPORT LATEST Arsenal transfer news LIVE: Ndidi bid, targets named, Ozil is ‘skiving little git’ Where Ancelotti ranks with every Premier League boss for trophies won REVEALED In a brief note on their website, Arsenal confirmed Kolasinac has: “Sustained an injury to his left knee.”They added that he: “Will be out for eight to ten weeks.”This news comes as a blow to new manager Unai Emery, who will have been hoping for a full strength side ahead of next week’s Premier League opener against champions Manchester City. Which teams do the best on Boxing Day in the Premier League era? However, he must now do without Sead Kolasinac until October at the earliest.The Gunners also updated on Aaron Ramsey’s situation, as he missed the Chelsea match with a calf strain.He will continue to be assessed and is aiming to return to training next week.
ITEM NO. 24 COUNTY MANAGER’S REPORT MARCH 20131. ROADS AND HOUSING DESIGN(a) Additional Funding for Drainage Works (b) Redistribution of Roads Grants(c) Specific Improvement Grants2. HOUSING AND CORPORATE SERVICES(a) Social Housing Investment Programme (b) Housing Adaptation Grant Schemes for Older People and People with a Disability3. WATER AND ENVIRONMENT(a) Operation of Civic Amenity Sites1. ROADS AND HOUSING DESIGNThe Council has received a number of circulars from the Department of Transport Tourism and Sport in relation to the non national roads grants already notified for 2013, along with some further indications regarding grants for 2014 and beyond. Copies of the circulars are attached as appendices. These notifications can be summarised under headings (a) and (b) below. Additional Funding for Drainage WorksThe Department has notified the Council of additional funding of €180,166 for drainage works for the county. The Department requires that any specific locations where works are carried out are identified and this should be agreed at an electoral area level by the 28th March and Members have been meeting on this locally already.Flexibility on Restoration Improvement Roads GrantsThe Department have confirmed greater flexibility in the allocation of funds under the roads strengthening grants for 2013, as follows: We are permitted to transfer up to 30% of the Restoration Improvement Grant to the Discretionary Grant.There is now no minimum length of scheme requirement under the Restoration Improvement Grant for 2013.There is no longer a requirement that a minimum of 90% of works in the Restoration Improvement category must be road reconstruction.The Department requires that the Council notify it of the revised discretionary maintenance and restoration improvement works by the 27th March. Meetings have been ongoing locally and a central workshop has been held in this regard.(c) Specific Improvement GrantsThe Department has also notified the Council that the Specific Improvement Grant will have to be terminated with effect from 2014 in order to maximise the funding available for repair and strengthening work.2. HOUSING AND CORPORATE SERVICES(a) Social Housing Investment ProgrammeDonegal County Council has received from the Department of the Environment, Community & Local Government, by letter dated 21st March, confirmation of funding in the sum of €1,310,535 under the above programme for 2013. This allocation is for Donegal County Council and the Town Councils in the County.The breakdown of this funding allocation is as follows, with the corresponding initial allocations from DECLG for 2012.Heading 2013 2012LA Housing € 0.345 M € 1.2 MVoluntary – CAS € 0.474 M € 0.8 MTravellers € 0.088 M € 0.3 MIWILs/Extensions €0.083 M €0.154 MImprovement of Housing Stock € 0.319 M € 0.545 MTotals €1,310,535 €2,999,022The allocation under LA Housing of €345,000 meets existing commitments in the current year and will enable the commencement of the second S.I. dwelling which was approved last July. The Department has advised that the projected capital allocations under LA Housing in 2014 and 2015 are likely to be further reduced, ruling out the potential for substantial carry-forward commitments into future years. The Department has further advised that, as a result, no new proposals will be considered for funding approval at this time. It is nonetheless expected that the 2014 allocation will include provision for the final S.I. dwelling, as this has already been approved under the three year programme.As Elected Members will note, a sum of €319,000 has been made available for Improvement of Housing Stock. There was considerable discussion during the adoption of the Budget 2013 in relation to the Housing Maintenance provision. While the 2013 provision from the Department is lower than what was available in 2012, the provision of €319,000 is welcome nonetheless and will assist the Council in terms of delivering on our overall objectives in this area.(b) Housing Adaptation Grant Schemes for Older People and People with a DisabilityThe Council has received notification of a combined allocation of €827,280 for the above schemes in 2013, which includes the Council’s own contribution of €165,456.At the end of 2012, €615,000 (200 applications) was spent, with works to a value of €63,000 (12 applications) under way at the 31st December. Commitments in respect of Grants, which had already been approved but not commenced at the end of the year, amounted to a further €181,000 (65 applications). There were a further 87 applications in the system at various stages of processing at an estimated value of €335,000. €37,000 has already been spent this year to the end of February.Given the budgetary limitations in 2013, the Council had confirmed that the co-funding requirements would be funded from the ring-fenced funds in preceding years, and where necessary from the Internal Capital Receipts account. In light of the allocation as now notified, I can confirm that sufficient monies are in place to meet the Council’s contribution and will enable the Council to continue to process grants in line with existing policy.Overall, it is believed existing policy is primarily meeting the objectives set and grants are now more targeted at delivering for those most in need, with essential works getting carried out.Elected Members have previously indicated their desire to review policy in this area and the Director of Service and the Chair of the Housing & Corporate Strategic Policy Committee have confirmed their willingness to review same at SPC level.3. WATER AND ENVIRONMENT(a) Operation of Civic Amenity SitesFollowing a public procurement process, the Council intends to enter into a concession contract with Bryson Recycling for the operation of the six Civic Amenity Sites at Laghey, Dungloe, Stranorlar, Letterkenny, Milford and Carndonagh. Bryson Recycling will operate the centres on the Council’s behalf and the contract, which will run for a period of three years, is expected to commence in April. The contract provides for an annual amount to be paid to the service provider in addition to the retention of gate fees. It is a condition of the contract that the existing charging regime and opening hours will be maintained. It is open to the contractor to reduce the charges and extend opening hours as they see fit.As the Members are aware, Bryson has been operating three sites (Stranorlar, Letterkenny and Milford) during 2012 arising from a previous public procurement process. The level of activity and customer feedback have both been positive during 2012. It is anticipated that, with the addition of the three centres, the upward trend in activity levels will continue.It is the Council’s intention, in collaboration with the service provider, to plan a comprehensive public awareness campaign and the Members will be updated with relevant information as the promotional campaign is rolled out.___________________Seamus NeelyCounty ManagerITEM NO. 24ADDENDUM TO COUNTY MANAGER’S REPORTMARCH 2013(Adjourned meeting of Donegal County Council – 15th April 2013)1. FINANCE & EMERGENCY SERVICES(a) Gorse/Wild Fires1. FINANCE & EMERGENCY SERVICES(a) Gorse/Wild FiresDonegal has experienced an increased incidence of gorse fires in the period from Thursday 28th March through to Sunday 14th April inclusive, with a total of 167 incidents throughout the County occurring during this period. Many of these incidents required multiple brigades to respond, particularly in instances where properties and commercial forestry were at immediate risk of damage and destruction. The retained fire fighters also responded to calls for assistance in neighbouring Counties Leitrim and Sligo, while a number of Northern Ireland Fire & Rescue Service brigades attended in areas where first response arrangements with them are in place.All brigade areas were called upon to a very great extent and the duration and scale of the incidents placed a substantial demand on the firefighters in a number of areas of the County in particular. I would like to acknowledge the commitment shown by the officers and members of the fire service during this very demanding time.I also want to thank the members of the Civil Defence, An Garda Síochána, Coillte and the members of the public who acted in a support role or who offered their assistance to the fire service during this time. The role of the media is also acknowledged in publicising the need for care during this time.Many areas of the County will remain susceptible to wild fires if the current period of rain comes to an end prior to the growing season starting in earnest. I would again call on land owners and members of the public to continue to be vigilant and to exercise caution to take all necessary measures to prevent gorse, heather, forestry and similar fires.Despite the best efforts of everyone, substantial damage has taken place throughout the County with properties damaged, commercial forestry lost and, sadly, loss to wildlife that can only be estimated. It is concerning that, in some instances, it would appear that the cause of ignition was not accidental. I would appeal to anyone, if aware of such instances, to advise their local Gardaí accordingly and to continue to be vigilant in future and that, should anything untoward be spotted, they advise their local Gardaí accordingly whilst also alerting the Fire authorities on 999 or 112 if any fire is noted.The additional costs associated with these incidents and call outs, the majority of which are un-attributable, will be calculated in due course and will be reflected in our accounts for the year.Number of Wild Fires in County Donegal – 159GORSE____________________Seamus NeelyCounty ManagerDONEGAL COUNTY COUNCIL: MANAGER’S REPORT TO MEMBERS IN FULL was last modified: April 16th, 2013 by BrendaShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:DONEGAL COUNTY COUNCIL: MANAGER’S REPORT TO MEMBERS IN FULL
The “The Signing of the Contract” for the extension to Deele College, Raphoe took place earlier this afternoon.The successful contractor, Glebe Builders, Donegal Town, will commence construction of the new 2,000m2 approx. school extension in the coming weeks at the existing School Site at Meetinghouse Street, Raphoe.The contract duration will be approximately 10 months. This is a particularly significant event for the staff, students and parents of Deele College, past and present, as well as the wider local community. Donegal Education and Training Board are most grateful to the Minister for Education and Skills together with her predecessors in the Department as well as its Officials in the School Building unit for authorising this project to proceed to construction stage.Donegal ETB would like to convey thanks to all those who have brought this Project to fruition, including:• Mr Joe Boyle, Principal and former Principal, Mr P.J. Mc Gowan (recently retired),• The staff, past and present of the College, • Past and present Chairpersons and members of the School’s Board of Management/Parents Association• Past and present Chairpersons and members of Donegal Education and Training Board• Mr Shaun Purcell, Chief Executive, Donegal ETB CONTRACT FOR EXTENSION TO DEELE COLLEGE SIGNED was last modified: December 18th, 2014 by Mark ForkerShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:BusinessFeaturesnews
Donegal Town is the place to be next weekend when Christmas officially arrives in Ireland’s Foodiest Town.Three days of unmissable food events, festive fun and shopping are taking place from Thursday 28th November to Saturday 30th November 2019.Donegal Town’s restaurants and cafes are hosting a ‘Savour the Flavour’ experience all weekend, while the Christmas lights switch-on, a shopping spree, ‘A Little Taste of Christmas in Donegal Town’, food tours of Donegal Town, and an afternoon of festivities at the Donegal Festive Craft Village will ensure there’s something for absolutely everyone. Advertisement “With all the Festive activities taking place next weekend; as part of “Savour the Flavour” Donegal Town promises to be most Christmassy place in the County. The twinkling lights and decorated shop windows will create a magical experience for all who visit Ireland’s Foodiest Town,” said Bernie Mulhern, Chairperson of the Donegal Town Community Chamber.See the programme of events in the poster below and scroll down for more details on all the exciting happenings:SAVOUR THE FLAVOUR OF DONEGAL TOWN“Savour the Flavour of Donegal Town” will create a distinctive experience by immersing visitors in the best food and drink Donegal Town has to offer. Advertisement Local hotels, restaurants and cafes will be creating dishes with local produce that will create a sense of place to include seasonal food and drink pairings, interactive experiences e.g. Food Tours of Donegal Town, Children’s Mexican Cookery Workshop, Meet the Butcher, Barista Coffee, Cocktail Making, Food and Craft Fair with Cookery Demonstrations, Kids Entertainment, Cultural and Heritage Activities, Guided Squirrel Walk. Something for everyone!“This event is part of Failte Ireland’s Taste the Island Initiative and is the perfect opportunity to showcase why we are Ireland’s Foodiest Town – the town that offers a unique stand-alone Food and Tourism Visitor Experience,” said Mary Mc Gettigan, one of the organisers.DONEGAL TOWN CHRISTMAS LIGHTS SWITCH ONThursday November 28th @ 7.00pmFinal preparations are being put in place to create the most magical atmosphere in Donegal Town for the annual “Switch On” of Donegal Town Christmas Lights taking place on Thursday 28th November 2019 @ 7.00 pm. Of course, the “Switch On” wouldn’t be complete without visits from the big man himself Santa Claus and his many MERRY friends! GET WRAPPED UP WELL come along and join us as the community prepares for most magical time of the year with a special appearance by the Bluestack Special Needs Foundation Choir. DONEGAL TOWN BUSINESSES FOCUS GROUP SHOPPING SPREECome and capture the festive mood and get your Christmas shopping all wrapped up during a special shopping extravaganza on Friday 29th and Saturday 30th November.“With the Christmas Lights already switched on the previous evening and late-night opening in participating stores; shoppers will be able to enjoy the Christmas ambience around town with discounts, special offers, in-store promotions and our €1000 mega prize draw and much more,” said Raymond Rooney, the Chairperson of Donegal Town Business Focus Group. Plus, you can meet the producers and crafters from Leghowney Country Market in The Weavers Loft of Magee of Donegal from 7.00pm on Friday 29th.A LITTLE TASTE OF CHRISTMAS IN DONEGAL TOWNThe finale of the weekend will be “A Little Taste of Christmas in Donegal Town” held in the Abbey Hotel on Saturday 30th November from 11.30am to 6.30 pm. There will be Exhibitor Stands where businesses can promote, sell, and take orders for Christmas etc. There will be a large variety of products not always available to the public, ranging from, cosmetics, jewellery, fashion, art, and loads of gift ideas for the Festive season. It will also give customers the opportunity to place orders for all their Christmas food requirements, and all of this can be done with very little effort in one venue.Getting the Festive Culinary Cookery Demonstrations off to a start will be Award Winning Author & Chef Brian Mc Dermott, Chris Mc Menamin – Ireland’s Best Chef and Executive Head Chef Harvey’s Point, Anthony Armstrong – Nesbitt Arms Hotel Ardara and Chef Influencer Zack Gallagher Irish Food Tours. Festive cocktails will also be shaken up by Wild Atlantic Distillery and Sliabh Liag Distillery.For the children there is a live interactive magic show with Mr Majestic from 4.30 pm – 6.00 pm, Face painting by Susan, Meet & Greet Mickey & Minnie. Bring your cuddly forever friend to life with Tj’s Teddies for Festive Family Photography Shoots.Ernan Mc Gettigan, Chairperson Christmas Lights Committee says “As you can see from all the above events Donegal Town is the must visit town to kickstart Christmas with family and friends. A draw will take place on the day for seasonal hampers and a year’s free parking in any of the public car parks in the town. I would like to take this opportunity to thank Donegal County Council who has given us this prize to help us with this fundraising event for Donegal Towns Christmas Lights.“On behalf of Donegal Town Community Chamber we would like to encourage everyone to come out and join in the festivities and support all that is local in particular Donegal Town’s Christmas lights display as with all events a lot of hard work is required to make these happen.”For further information follow us on: www.atasteofdonegal.com and also on Donegal Town Community and A Taste of Donegal Food Festival Facebook Pages. DONEGAL FESTIVE CRAFT VILLAGE AN AFTERNOON OF FESTIVITIES The Christmas at The Donegal Craft Village event takes place on Saturday 30th November between 1-4pm.Why not call by the Festive Craft Village to sip on some cosy mulled wine, nibble on festive home bakes, treat yourself to fabulous discounts in all the craft shops and all this whilst listening to the extremely talented Donegal Contemporary Chorus as they gather around our giant Christmas tree, singing festive and contemporary songs! It’s going to be wonderful and for the children we have children’s face painting, festive treats and hot chocolate and marshmallows. This is a FREE event.The event sees the craft village gathering together each Christmas to thank all customers for their support and custom each year.With all this and more – a visit to Donegal Town is a must!Donegal Town a must-visit for food, fun and shopping this Christmas was last modified: November 18th, 2019 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:A Little Taste of Christmas in Donegal TownA Taste of Donegalchristmas lights switch-onDonegal Town Communityeventsretailsavour the flavour donegal townshoppingSouth Donegal
Embed from Getty ImagesIpswich boss Paul Lambert refused to blame Jon Nolan for a costly mistake against QPR.Their 3-0 defeat meant Town remain bottom of the Championship and have lost five of their last six away matches.They conceded twice in four first-half minutes at Loftus Road, where the opening goal came after Nolan gave the ball away.After keeper Dean Gerken failed to hold Nahki Wells’ shot, Pawel Wszolek pounced on the rebound to score.Joel Lynch doubled QPR’s lead, and Wells added a third with 16 minutes remaining.Lambert said: “For the first goal we’ve got the ball, are on top of the game, and Jon’s tried that pass – which is fine because I’m telling them to play.“There’s no blame attached to him whatsoever. The great thing about it is that he kept on trying to take the ball. It takes a big player to do that when you’ve made a mistake.“He’s playing really well and I’ll never criticise somebody for trying to get on the ball.“I know what it’s like and there’s no player alive that doesn’t make a mistake.“OK he made a mistake, but he goes again and I was delighted that he kept on going and never stopped trying to do things, which is great.”Ipswich are seven points from safety but Lambert sees signs of progress and is optimistic they will climb away from trouble.“A lot can change very quickly and there’s a long way to go,” he said.“As long as you finish above that line, it doesn’t matter where you are.“Whether we deserved to win this game or not I don’t know, but performance-wise we were dominating the ball for long spells.“The difference was at both ends. I don’t think we did enough in the attacking third and didn’t defend as well as we should.” Follow West London Sport on TwitterFind us on Facebookby Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksRecommended for youAspireAbove.comRemember Pauley Perrette? Try Not To Smile When You See Her NowAspireAbove.comUndoLifestly.com25 Celebs You Didn’t Realize Are Gay – No. 8 Will Surprise WomenLifestly.comUndoUsed Cars | Search AdsUsed Cars in Tuen Mun Might Be Cheaper Than You ThinkUsed Cars | Search AdsUndoTopCars15 Ugliest Cars Ever MadeTopCarsUndoezzin.com20 Breathtaking Places to See Before You Dieezzin.comUndoFood World Magazine15 Fruits that Burn Fat Like CrazyFood World MagazineUndoDrhealth35 Foods That Should Never Be Placed in the RefrigeratorDrhealthUndoHappyTricks.comHer House Always Smells Amazing – Try her Unique Trick!HappyTricks.comUndo
Click here if you are having trouble viewing the slideshow on a mobile device.OAKLAND — Marco Estrada is becoming an early candidate for the A’s hard-luck loss pitcher on the staff.For a third consecutive start, the right-hander allowed three runs or less in a start that resulted in an A’s loss, this time defeated 6-3 by the Boston Red Sox Wednesday night.Estrada appeared to induce an inning-ending double play ball against Rafael Devers that would have preserved a two-run lead, but an errant …
Here is an assortment of recently-reported biological marvels at the cellular level. Researchers into creation and evolution explanations may wish to delve into these more deeply.Clock Conductor: The brain is a “time machine,” reports EurekAlert on research at Duke University about the human biological clock. Each structure in the brain has a resonant frequency of oscillations, like the ticking of a clock. How do they get coordinated? Think of the tune-up at the beginning of a concert, says Catalin Buhusi of Duke: “It’s like a conductor who listens to the orchestra, which is composed of individual musicians. Then, with the beat of his baton, the conductor synchronizes the orchestra so that listeners hear a coordinated sound.”Molecular Scissors: MicroRNAs (miRNA) have been implicated in recent years with the regulation of genes (09/08/2005), including silencing genes that need to be slowed down or stopped. EurekAlert reported on work by Wistar Institute that detected a “molecular scissors”action involving three independent parts: “The two enzymes in the complex are like two scissors working together in a concerted fashion, connected and coordinated by the third member of the complex,” said Ramin Shiekhattar. The activity apparently occurs without any expenditure of ATP energy.Nerve Code: Scientists at Howard Hughes Medical Institute were surprised at an unexpected discovery: neuron development follows a code – “an organized relationship between Hox proteins, their chromosomal organization, and the differentiation and connectivity of motor neuron pools.” The discovery of a combinatorial code, which governs three levels of motor neuron organization, “shows how the nervous system can generate the huge diversity of neurons necessary for a complex task like locomotion.” Song and Pfaff of the Salk Institute reported on this surprising find in Cell, titling their article, “Hox Genes: The Instructors Working at Motor Pools.”Sprinting Motor: Like a sprinter crouching at the block before sprinting, kinesin stores up energy before its 7.8 nanometer leaps, reported Fisher and Kim in PNAS last month. And like a strong sprinter, it’s not a pushover: “sideways lurching is not supported.”Give Me Iron, or Give Me Death: Taylor et al., writing in PNAS, studied the structure of a yeast enzyme named Fet3p essential to oxidizing both iron and copper. The regulation of these metal ions is essential; Taylor et al. said, “Loss of the Fe(II) oxidation catalyzed by these proteins results in a spectrum of pathological states, including death.”Gecko Rain Dance: Geckos have a billion spatula-shaped structures at the ends of the hairs on their feet that allow them to “adhere to nearly all surface topographies.” Huber et al. in PNAS explored the capillary action on a single spatula and found that “humidity contributes significantly to gecko adhesion on a nanoscopic level.” They were interested in learning about gecko feet “for the development of artificial biomimetic attachment systems.”Packaging into the Cell: Some cargoes get wrapped in membrane and are delivered right through the cell exterior; this is called clathrin-mediated endocytosis. Kaksonen, Toret and Drubin at UC Berkeley found that “four protein modules that cooperate to drive coat formation, membrane invagination, actin-meshwork assembly, and vesicle scission during clathrin/actin-mediated endocytosis.” The clathrin itself (an interesting three-pronged protein that forms geodesic structures around the vesicle) “facilitates the initiation of endocytic-site assembly but is not needed for membrane invagination or vesicle formation.” The work was reported in Cell; see also EurekAlert summary.Not Just a Recycle Bin: The proteasome is getting more respect. This “large multiprotein complex” is critical to the degradation of proteins tagged for recycling. Baker and Grant reported in Cell that the proteasome was found involved in gene activation, adding to a “growing body of evidence indicating that the proteasome has nonproteolytic functions.”Sharper Image: Peter Moore in Science was glad about the “ribosomal coup” performed by Schuwirth et al. in the same issue, who imaged the bacterial ribosome at 3.5 angstrom resolution. This molecular machine, the protein assembly factory, has moving parts. Moore said, “The two subunits of the ribosome not only communicate during protein synthesis, they also engage in coordinated, relative motions.”Bacterial Centipedes: Did you know that bacteria can walk? They project little feet called pili that adhere to surfaces; as the bacteria retract them, they pull the bacteria along in a crawling motion. Researchers at UC Berkeley reporting in Science found a signaling molecule that they watched traveling from one end of the bacterium to the other when the organism needed to change directions. They figured that this enzyme, FrzS, constituted a chemosensory system that hops onto the intracellular highway and orchestrates the formation of the pili.Mr. Peabody Gains Respect: Little specks called P-bodies near the nucleus never had so much limelight. Jean Marx, writing in Science, told how scientists used to think they were just trash cans for used messenger RNAs (mRNA), a dead-end job. Now, it appears that these “tiny speckles at the heart of the cell’s machinery” are active, critical players in the regulation of protein synthesis. They act like routers, holding onto mRNA transcripts while deciding which get used or recycled. Are they important? When they go awry, cancer and autoimmune diseases can result.Bees Under the Floodlights: Humans can distinguish red, yellow and other colors under different lighting conditions, an ability called color constancy. Bees have this talent, too. To prove that weird lighting in a natural setting doesn’t throw them off, two London scientists put bumblebees in a specially-lit chamber. All the flowers had black backgrounds, and four colored lights could alter the ambience. They found that “bees can generate color-constant behavior by encoding empirically significant contrast relationships between statistically dependent, but visually distinct, stimulus elements of scenes” – spoken like a scientist, but the bees get the applause.These 12 brief glimpses at recent science literature hint at the stream of discoveries being made that uncover more and more complexity and coordinated design. Most of these papers don’t even mention evolution; none of them try to account for the origin of the complex structures they studied. On the contrary, if the reports had been written by members of the intelligent design movement, no one would be able to tell the difference. Both groups would express astonishment – but for different reasons.(Visited 13 times, 1 visits today)FacebookTwitterPinterestSave分享0